2. Academic Validation
  3. Fungal metabolites. Part 14. Novel potent immunosuppressants, mycestericins, produced by Mycelia sterilia

Fungal metabolites. Part 14. Novel potent immunosuppressants, mycestericins, produced by Mycelia sterilia

  • J Antibiot (Tokyo). 1994 Apr;47(4):420-33. doi: 10.7164/antibiotics.47.420.
S Sasaki 1,  R Hashimoto,  M Kiuchi,  K Inoue,  T Ikumoto,  R Hirose,  K Chiba,  Y Hoshino,  T Okumoto,  T Fujita
Affiliations

Affiliation

  • 1 Faculty of Pharmaceutical Sciences, Kyoto University, Japan.
PMID: 8195042 DOI: 10.7164/antibiotics.47.420
Abstract

Mycestericins A, B, C, D and E were isolated from the culture broth of Mycelia sterilia ATCC 20349 along with thermozymocidin (= myriocin). Their structures were elucidated on the basis of spectroscopic studies and chemical evidence. The acetate of mycestericin C was identical with the acetate of 6,7-dihydromyriocin. Mycestericins suppressed the proliferation of lymphocytes in the mouse allogeneic mixed lymphocyte reaction, with a potency similar to that of myriocin.

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