2. Academic Validation
  3. The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction

The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction

  • Nature. 1993 Nov 11;366(6451):129-35. doi: 10.1038/366129a0.
M Müller 1,  J Briscoe,  C Laxton,  D Guschin,  A Ziemiecki,  O Silvennoinen,  A G Harpur,  G Barbieri,  B A Witthuhn,  C Schindler
Affiliations

Affiliation

  • 1 Imperial Cancer Research Fund Laboratories, London, UK.
PMID: 8232552 DOI: 10.1038/366129a0
Abstract

We have produced a cell line which lacks the protein tyrosine kinase JAK1 and is completely defective in interferon response. Complementation of this mutant with JAK1 restored the response, establishing the requirement for JAK1 in both the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and Tyk2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes.

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