2. Academic Validation
  3. A new antitumor substance, BE-18591, produced by a streptomycete. I. Fermentation, isolation, physico-chemical and biological properties

A new antitumor substance, BE-18591, produced by a streptomycete. I. Fermentation, isolation, physico-chemical and biological properties

  • J Antibiot (Tokyo). 1993 Dec;46(12):1799-803. doi: 10.7164/antibiotics.46.1799.
K Kojiri 1,  S Nakajima,  H Suzuki,  A Okura,  H Suda
Affiliations

Affiliation

  • 1 New Drug Discovery Research Laboratories, Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd., Japan.
PMID: 8294236 DOI: 10.7164/antibiotics.46.1799
Abstract

New antitumor substance, designated BE-18591, was isolated from the culture broth of a streptomycete, strain BA18591. The active principle was extracted from mycelium by methanol and purified by silica gel chromatography. BE-18591 inhibited the growth of MKN-45 human stomach Cancer cell line as well as P388 cell line. In in vivo experiments, BE-18591 inhibited the growth of Ehrlich ascites tumor.BE-18591 showed antimicrobial activity against Gram-positive and some Gram-negative bacteria.

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