2. Academic Validation
  3. New antiviral antibiotics, kistamicins A and B. II. Structure determination

New antiviral antibiotics, kistamicins A and B. II. Structure determination

  • J Antibiot (Tokyo). 1993 Dec;46(12):1812-8. doi: 10.7164/antibiotics.46.1812.
N Naruse 1,  M Oka,  M Konishi,  T Oki
Affiliations

Affiliation

  • 1 Bristol-Myers Squibb Research Institute, Tokyo, Japan.
PMID: 8294238 DOI: 10.7164/antibiotics.46.1812
Abstract

The structures of antiviral Antibiotics kistamicins A and B have been determined by a combination of chemical degradation and spectral analysis. They are commonly composed of D-tyrosine, 3,5-dihydrophenylglycine, a biphenyl ether bis-amino acid, and a diphenyl substituted indole tris-amino acid, forming a tricyclic ring structure. Kistamicin B possessed a phenethylamide at the amino terminal of kistamicin A. They are structurally related to the nuclei of the vancomycin group Antibiotics particularly to Antibiotic complestatin.

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