2. Academic Validation
  3. Structure and function of the bacteriophage T7 RNA polymerase (or, the virtues of simplicity)

Structure and function of the bacteriophage T7 RNA polymerase (or, the virtues of simplicity)

  • Cell Mol Biol Res. 1993;39(4):385-91.
W T McAllister 1
Affiliations

Affiliation

  • 1 Department of Microbiology and Immunology, Morse Institute of Molecular Genetics, SUNY Health Science Center, Brooklyn 11203-2098.
PMID: 8312975
Abstract

A consideration of the properties of a number of mutants of T7 RNA polymerase, together with emerging structural information (Sousa et al., 1993) allows an interpretation of the the mechanics of transcription by this relatively simple RNA polymerase. Evidence indicating features in common with other nucleotide polymerases (such as DNA polymerases and reverse transcriptases) is reviewed.

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