2. Academic Validation
  3. A new aminoglycoside antibiotic complex--the seldomycins. III. The structures of seldomycin factors 1 and 2+

A new aminoglycoside antibiotic complex--the seldomycins. III. The structures of seldomycin factors 1 and 2+

  • J Antibiot (Tokyo). 1977 Jan;30(1):31-8. doi: 10.7164/antibiotics.30.31.
R S Egan,  A C Sinclair,  R L De Vault,  J B McAlpine,  S L Mueller,  P C Goodley,  R S Stanaszek,  M Cirovic,  R J Mauritz,  L A Mitscher,  K Shirahata,  S Sato,  T Iida
PMID: 838630 DOI: 10.7164/antibiotics.30.31
Abstract

The structures of seldomycin factors 1 and 2 have been determined by consideration of chemical degradation and spectral properties. Factor 1, also known as XK-88-1, is shown to be 6-O-(2-amino-2-deoxy-alpha-D-xylopyranosyl) paromamine (1) and factor 2, also known as XK-88-2, is shown to be 4'-deoxy-neamine (2). Mass spectral evidence has been obtained that suggests the most probable structure for seldomycin factor 3, also known as XK-88-3, is 6'-amino-6'-deoxyseldomycin factor 1 (12).

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