2. Academic Validation
  3. Augmentation of human natural killer cells by splenopentin analogs

Augmentation of human natural killer cells by splenopentin analogs

  • FEBS Lett. 1993 Feb 8;317(1-2):93-5. doi: 10.1016/0014-5793(93)81498-o.
A Rastogi 1,  V K Singh,  S Biswas,  W Haq,  K B Mathur,  S S Agarwal
Affiliations

Affiliation

  • 1 Division of Biopolymers, Central Drug Research Institute, Lucknow, India.
PMID: 8428639 DOI: 10.1016/0014-5793(93)81498-o
Abstract

Splenopentin, Arg-Lys-Glu-Val-Tyr (SP-5) and its synthetic analogs; Arg-D-Lys-Glu-Val-Tyr (pentapeptide 1), Lys-Lys-Glu-Val-Tyr (2), D-Lys-Lys-Glu-Val-Tyr (3), Arg-Lys-Gly-Val-Tyr (4), and Arg-Lys-Gln-Val-Tyr (5) have been examined for augmentation of human natural killer (NK) cell activity and human T-cell transformation response. Pentapeptides 2 and 3 were found to significantly augment the in vitro human NK cell activity. However, none of them had any effect on lymphocyte proliferative responses.

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