2. Academic Validation
  3. Discovery of an angiotensin II binding inhibitor from a Cytospora sp. using semi-automated screening procedures

Discovery of an angiotensin II binding inhibitor from a Cytospora sp. using semi-automated screening procedures

  • J Antibiot (Tokyo). 1996 Feb;49(2):119-23. doi: 10.7164/antibiotics.49.119.
S Stevens-Miles 1,  M A Goetz,  G F Bills,  R A Giacobbe,  J S Tkacz,  R S Chang,  M Mojena,  I Martin,  M T Diez,  F Pelaez,  O D Hensens,  T Jones,  R W Burg,  Y L Kong,  L Huang
Affiliations

Affiliation

  • 1 Merck Research Laboratories, Rahway, New Jersey 07065, USA.
PMID: 8621349 DOI: 10.7164/antibiotics.49.119
Abstract

Cytosporin A, B and C, three antagonists of [125I]-angiotensin II binding to rat adrenal glands were discovered in fermentations of an endophytic Cytospora sp. during routine screening using semi-automated procedures. The most potent of these displayed an IC50 of 1.5-3 microM and was specific for angiotensin II AT2.

Figures
Products