2. Academic Validation
  3. Indolopyridoquinazoline alkaloids with antiplatelet aggregation activity from Zanthoxylum integrifoliolum

Indolopyridoquinazoline alkaloids with antiplatelet aggregation activity from Zanthoxylum integrifoliolum

  • Planta Med. 1996 Apr;62(2):175-6. doi: 10.1055/s-2006-957846.
W S Sheen,  I L Tsai,  C M Teng,  F N Ko,  I S Chen
PMID: 8657756 DOI: 10.1055/s-2006-957846
Abstract

Bioassay-guided fractionation led to the isolation of three indolopyridoquinazoline Alkaloids, 1-hydroxyrutaecarpine, rutaecarpine, and 1-methoxyrutaecarpine as the active principles of antiplatelet aggregation in vitro, from the chloroform-soluble part of the fruit of Zanthoxylum integrifoliolum (Rutaceae). 1-Hydroxyrutaecarpine exhibited antiplatelet activity induced by AA and showed an IC50 value of CA. 1-2 micrograms/ml.

Figures
Products