2. Academic Validation
  3. The novel antibacterial peptide ceratotoxin A alters permeability of the inner and outer membrane of Escherichia coli K-12

The novel antibacterial peptide ceratotoxin A alters permeability of the inner and outer membrane of Escherichia coli K-12

  • Curr Microbiol. 1996 Jul;33(1):40-3. doi: 10.1007/s002849900071.
L Marri 1,  R Dallai,  D Marchini
Affiliations

Affiliation

  • 1 Dipartimento di Biologia Molecolare, Sezione di Microbiologia, Università di Siena, Italy.
PMID: 8661687 DOI: 10.1007/s002849900071
Abstract

Ceratotoxins are Antibacterial 3-kDa amphiphilic Peptides isolated from the female reproductive apparatus of the medfly Ceratitis capitata. The Antibacterial activity of a chemically synthesized ceratotoxin A (ctx A) has been investigated. Ctx A was mainly active against Gram-negative organisms, and it had a lytic effect on nongrowing Escherichia coli K-12. Data showed that ctx A alters both the outer and the inner membrane of E.coli K-12 cells.

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