2. Academic Validation
  3. Synthesis of acyclo-C-nucleosides in the imidazo[1,2-a]pyridine and pyrimidine series as antiviral agents

Synthesis of acyclo-C-nucleosides in the imidazo[1,2-a]pyridine and pyrimidine series as antiviral agents

  • J Med Chem. 1996 Jul 5;39(14):2856-9. doi: 10.1021/jm9507901.
A Gueiffier 1,  M Lhassani,  A Elhakmaoui,  R Snoeck,  G Andrei,  O Chavignon,  J C Teulade,  A Kerbal,  E M Essassi,  J C Debouzy,  M Witvrouw,  Y Blache,  J Balzarini,  E De Clercq,  J P Chapat
Affiliations

Affiliation

  • 1 Laboratoire de Chimie Organique Pharmaceutique, URA-CNRS 1111, Montpellier, France.
PMID: 8709116 DOI: 10.1021/jm9507901
Abstract

The synthesis and the Antiviral activities of C-3 acyclic nucleoside analogues of imidazo[1,2-a]pyridine and pyrimidine are reported. From these compounds, 20, 21, 22, 23, 28, and 34 showed a specific activity against cytomegalovirus and/or varicella-zoster virus.

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