2. Academic Validation
  3. BCX-34: a novel T-cell selective immunosuppressant: purine nucleoside phosphorylase (PNP) inhibitor

BCX-34: a novel T-cell selective immunosuppressant: purine nucleoside phosphorylase (PNP) inhibitor

  • Artif Organs. 1996 Aug;20(8):849-52. doi: 10.1111/j.1525-1594.1996.tb04557.x.
Y Wada 1,  A Yagihashi,  K Terasawa,  N Miyao,  K Hirata,  J Cicciarelli,  Y Iwaki
Affiliations

Affiliation

  • 1 First Department of Surgery, Sapporo Medical University, School of Medicine, Japan.
PMID: 8853794 DOI: 10.1111/j.1525-1594.1996.tb04557.x
Abstract

We evaluated the efficacy of a new purine nucleoside phosphorylase inhibitor, BCX-34, as an immunosuppressive agent. BCX-34 showed a complete inhibitory effect on the proliferation of T-cells in an in vitro system, whereas no influence was observed in B-cell lines. In addition, it was revealed that this inhibitory effect was not due to the suppression of interleukin-2 production. Therefore, BCX-34 might be a potentially useful drug that can be used in combination, not competition, with cyclosporine A and FK506.

Figures
Products