2. Academic Validation
  3. Novel antiplatelet constituents from formosan moraceous plants

Novel antiplatelet constituents from formosan moraceous plants

  • J Nat Prod. 1996 Sep;59(9):834-8. doi: 10.1021/np960376j.
C N Lin 1,  C M Lu,  H C Lin,  S C Fang,  B J Shieh,  M F Hsu,  J P Wang,  F N Ko,  C M Teng
Affiliations

Affiliation

  • 1 School of Pharmacy, Kaohsiung Medical College, Taiwan, Republic of China.
PMID: 8864236 DOI: 10.1021/np960376j
Abstract

Sixteen constituents from Formosan Moraceous Plants were tested for their antiplatelet activities in rabbit platelet suspension and human platelet-rich plasma. Cycloartocarpin A, cycloheterophyllin, broussochalcone A, kazinol A, broussoaurone A, and broussoflavonol F showed strong inhibition of arachidonic acid (AA)-induced platelet aggregation. Of the compounds tested, broussochalcone A exhibited the most potent inhibition of platelet aggregation induced by AA (IC50 = 6.8 microM). The antiplatelet effects of cycloheterophyllin, broussochalcone A, kazinol B, broussoaurone A, and broussoflavonol F are partially due to an inhibitory effect on cyclooxygenase.

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