2. Academic Validation
  3. Chlorinated annonaceous acetogenins and their bioactivities

Chlorinated annonaceous acetogenins and their bioactivities

  • J Nat Prod. 1996 Oct;59(10):994-6. doi: 10.1021/np9605089.
Q Ye 1,  G Shi,  K He,  J L McLaughlin
Affiliations

Affiliation

  • 1 Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Pardue University, West Lafayette, Indiana 47907, USA.
PMID: 8904848 DOI: 10.1021/np9605089
Abstract

4(S)-Chloro-4-deoxygigantetrocin A and 4(S), 18-dichloro-4,18-dideoxyasimilobin were obtained by treating gigantetrocin A with triphenylphosphine and CCl4. The structures were determined by spectroscopic methods. The chlorinated compounds show decreased bioactivities in the brine shrimp lethality test and against human tumor cell lines.

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