The transcriptional coactivators p300 and CBP are histone acetyltransferases

Cell. 1996 Nov 29;87(5):953-9. doi: 10.1016/s0092-8674(00)82001-2.

V V Ogryzko ¹, R L Schiltz, V Russanova, B H Howard, Y Nakatani

Affiliations

Affiliation

1 Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-2753, USA.

PMID: 8945521 DOI: 10.1016/s0092-8674(00)82001-2

Abstract

p300/CBP is a transcriptional adaptor that integrates signals from many sequence-specific activators via direct interactions. Various cellular and viral factors target p300/CBP to modulate transcription and/or cell cycle progression. One such factor, the cellular p300/CBP associated factor (PCAF), possesses intrinsic Histone Acetyltransferase activity. Here, we demonstrate that p300/CBP is not only a transcriptional adaptor but also a Histone Acetyltransferase. p300/CBP represents a novel class of acetyltransferases in that it does not have the conserved motif found among various other acetyltransferases. p300/CBP acetylates all four core histones in nucleosomes. These observations suggest that p300/CBP acetylates nucleosomes in concert with PCAF.

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