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  3. Studies on new antitumor antibiotics, leptofuranins A, B, C and D II. Physiocochemical properties and structure elucidation

Studies on new antitumor antibiotics, leptofuranins A, B, C and D II. Physiocochemical properties and structure elucidation

  • J Antibiot (Tokyo). 1996 Oct;49(10):980-4. doi: 10.7164/antibiotics.49.980.
Y Hayakawa 1,  K Sohda,  H Seto
Affiliations

Affiliation

  • 1 Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
PMID: 8968390 DOI: 10.7164/antibiotics.49.980
Abstract

The structures of new antitumor Antibiotics, leptofuranins A, B, C and D were elucidated to be as shown in Fig. 1 by NMR spectral analysis including a variety of two-dimensional techniques. The leptofuranins are novel leptomycin-related substances containing a tetrahydrofuran ring. Leptofuranins C and D were revealed to be in tautomeric isomerism and their relative stereochemistries were analyzed by NOESY experiments.

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