2. Academic Validation
  3. Biologically active acylglycerides from the berries of saw-palmetto (Serenoa repens)

Biologically active acylglycerides from the berries of saw-palmetto (Serenoa repens)

  • J Nat Prod. 1997 Apr;60(4):417-8. doi: 10.1021/np960552o.
H Shimada 1,  V E Tyler,  J L McLaughlin
Affiliations

Affiliation

  • 1 Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907, USA.
PMID: 9134750 DOI: 10.1021/np960552o
Abstract

Brine shrimp lethality-directed fractionation of the 95% EtOH extract of the powdered, dried berries of Serenoa repens (Bart.) Small (saw-palmetto) (Palmae) led to the isolation of two monoacylglycerides, 1-monolaurin (1) and 1-monomyristin (2). Compounds 1 and 2 showed moderate biological activities in the brine shrimp lethality test and against renal (A-498) and pancreatic (PACA-2) human tumor cells; borderline cytotoxicity was exhibited against human prostatic (PC-3) cells. The fruits and extracts of saw-palmetto are taken orally as an herbal medicine to prevent prostatic hyperplasias.

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