2. Academic Validation
  3. Cyclothialidine analogs, novel DNA gyrase inhibitors

Cyclothialidine analogs, novel DNA gyrase inhibitors

  • J Antibiot (Tokyo). 1997 May;50(5):402-11. doi: 10.7164/antibiotics.50.402.
K Yamaji 1,  M Masubuchi,  F Kawahara,  Y Nakamura,  A Nishio,  S Matsukuma,  M Fujimori,  N Nakada,  J Watanabe,  T Kamiyama
Affiliations

Affiliation

  • 1 Nippon Roche Research Center, Kanagawa, Japan.
PMID: 9207910 DOI: 10.7164/antibiotics.50.402
Abstract

DNA gyrase inhibitors, cyclothialidines B, C, D and E were isolated from four Streptomycete strains (NR 0659, NR 0660, NR 0661 and NR 0662). Their structures have been elucidated based on the amino acid analysis of the hydrolysates, NMR and HRFAB-MS experiments and shown to be cyclothialidine analogs. The absolute stereochemistry has been determined by the chiral HPLC analysis of the hydrolysates. Cyclothialidines B, D and E are novel and potent inhibitors of DNA gyrase.

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