2. Academic Validation
  3. 4-amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide, a new, potent fasciolicide

4-amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide, a new, potent fasciolicide

  • J Med Chem. 1977 Sep;20(9):1225-7. doi: 10.1021/jm00219a025.
H Mrozik,  R J Bochis,  P Eskola,  A Matzuk,  S Waksmunski,  L E Olen,  G Schwartzkopf Jr,  A Grodski,  B O Linn,  A Lusi,  M T Wu,  C H Shunk,  L H Peterson,  J D Milkowski,  D R Hoff,  P Kulsa,  D A Ostlind,  W C Campbell,  R F Riek,  R E Harmon
PMID: 926125 DOI: 10.1021/jm00219a025
Abstract

The synthesis and fasciolicidal activity of 4-amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide are reported. A single dose of 15 mg/kg was effective in removing over 90% of immature Fasciola hepatica from sheep (6 weeks after Infection) and calves (8 weeks after Infection). A 2.5 mg/kg dose removed over 90% of mature (16 weeks old) liver fluke from sheep. Single oral doses up to 400 mg/kg were tolerated by sheep without gross toxic symptoms.

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