2. Academic Validation
  3. Novel biological response modifiers: phthalimides with tumor necrosis factor-alpha production-regulating activity

Novel biological response modifiers: phthalimides with tumor necrosis factor-alpha production-regulating activity

  • J Med Chem. 1997 Aug 29;40(18):2858-65. doi: 10.1021/jm970109q.
H Miyachi 1,  A Azuma,  A Ogasawara,  E Uchimura,  N Watanabe,  Y Kobayashi,  F Kato,  M Kato,  Y Hashimoto
Affiliations

Affiliation

  • 1 Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
PMID: 9288167 DOI: 10.1021/jm970109q
Abstract

Novel N-substituted phthalimides (2-substituted 1H-isoindole-1,3-diones) were prepared, and their effects on tumor necrosis factor-alpha (TNF-alpha) production by human leukemia cell line HL-60 stimulated with 12-O-tetradecanoylphorbol 13-acetate (TPA) or okadaic acid (OA) were examined. A structure-activity relationship study of the N-phenylphthalimides and N-benzylphthalimides revealed that their enhancing effect on TPA-induced TNF-alpha production by HL-60 cells and their inhibiting effect on OA-induced TNF-alpha production by HL-60 cells are only partially correlated.

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