2. Academic Validation
  3. C-terminal domain of transcription cofactor PC4 reveals dimeric ssDNA binding site

C-terminal domain of transcription cofactor PC4 reveals dimeric ssDNA binding site

  • Nat Struct Biol. 1997 Nov;4(11):900-3. doi: 10.1038/nsb1197-900.
J Brandsen,  S Werten,  P C van der Vliet,  M Meisterernst,  J Kroon,  P Gros
PMID: 9360603 DOI: 10.1038/nsb1197-900
Abstract

The crystal structure of human replication and transcription cofactor PC4CTD reveals a dimer with two single-stranded (ss)DNA binding channels running in opposite directions to each other. This arrangement suggests a role in establishment or maintenance of melted DNA at promoters or origins of replication.

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