2. Academic Validation
  3. Four new cytotoxic germacranolides from Carpesium divaricatum

Four new cytotoxic germacranolides from Carpesium divaricatum

  • J Nat Prod. 1997 Nov;60(11):1199-202. doi: 10.1021/np970157d.
D K Kim 1,  N I Baek,  S U Choi,  C O Lee,  K R Lee,  O P Zee
Affiliations

Affiliation

  • 1 Natural Products Laboratory, College of Pharmacy, Sung Kyun Kwan University, Suwon, Korea.
PMID: 9392887 DOI: 10.1021/np970157d
Abstract

In a bioassay-guided search for cytotoxic compounds from higher Plants of South Korea, four new Sesquiterpenes of the germacranolide type, named cardivins A (1), B (2), C (3), and D (4), have been isolated from the aerial parts of Carpesium divaricatum. Structures of these compounds were elucidated on the basis of spectroscopic techniques. Compounds 1, 2, 3, and 4 showed cytotoxicity to the human tumor cells, A-549 (nonsmall cell lung), SK-OV-3 (ovary), SK-MEL-2 (skin), XF-498 (central nervous system), and HCT-15 (colon).

Figures