2. Academic Validation
  3. Amphistin, a new melanogenesis inhibitor, produced by an actinomycete

Amphistin, a new melanogenesis inhibitor, produced by an actinomycete

  • J Antibiot (Tokyo). 1997 Oct;50(10):808-14. doi: 10.7164/antibiotics.50.808.
N Arai 1,  K Shiomi,  S Takamatsu,  K Komiyama,  M Shinose,  Y Takahashi,  Y Tanaka,  Y Iwai,  J R Liu,  S Omura
Affiliations

Affiliation

  • 1 Research Center for Biological Function, Kitasato Institute, Tokyo, Japan.
PMID: 9402984 DOI: 10.7164/antibiotics.50.808
Abstract

A new melanogenesis inhibitor, named amphistin, was isolated from the fermentation broth of an actinomycete strain KP-3052. Amphistin was purified from the culture filtrate by the combination of cation exchange, gel filtration, and aminosilyl silica gel chromatographic methods. The structure of amphistin was elucidated as gamma-(beta-histidinoalanino)homoalanine by NMR experiments including 1H-15N HMBC experiment and Other spectroscopic analyses. Amphistin inhibited the melanogenesis of B16 melanoma cells at concentration of 6.8 microM.

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