2. Academic Validation
  3. The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain

The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain

  • Immunity. 1997 Dec;7(6):813-20. doi: 10.1016/s1074-7613(00)80399-4.
M A Degli-Esposti 1,  W C Dougall,  P J Smolak,  J Y Waugh,  C A Smith,  R G Goodwin
Affiliations

Affiliation

  • 1 Department of Biochemistry, Immunex Corporation, Seattle, Washington 98101, USA. mdegliesposti@immunex.com
PMID: 9430226 DOI: 10.1016/s1074-7613(00)80399-4
Abstract

A fourth member of the emerging TRAIL receptor family, TRAIL-R4, has been cloned and characterized. TRAIL-R4 encodes a 386-amino acid protein with an extracellular domain showing 58%-70% identity to those of TRAIL-R1, TRAIL-R2, and TRAIL-R3. The signaling capacity of TRAIL-R4 is similar to that of TRAIL-R1 and TRAIL-R2 with respect to NF-kappaB activation, but differs in its inability to induce Apoptosis. Yet TRAIL-R4 retains a C-terminal element containing one third of a consensus death domain motif. Transient overexpression of TRAIL-R4 in cells normally sensitive to TRAIL-mediated killing confers complete protection, suggesting that one function of TRAIL-R4 may be inhibition of TRAIL cytotoxicity. Like TRAIL-R1 and TRAIL-R2, this receptor shows widespread tissue expression. The human TRAIL-R4 gene has been mapped to chromosome 8p22-21, clustered with three other TRAIL receptors.

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