2. Academic Validation
  3. Two pimarane diterpenoids from Ephemerantha lonchophylla and their evaluation as modulators of the multidrug resistance phenotype

Two pimarane diterpenoids from Ephemerantha lonchophylla and their evaluation as modulators of the multidrug resistance phenotype

  • J Nat Prod. 1998 Jan;61(1):112-5. doi: 10.1021/np970065o.
G X Na 1,  T S Wang,  L Yin,  Y Pan,  Y L Guo,  G A LeBlanc,  M G Reinecke,  W H Watson,  M Krawiec
Affiliations

Affiliation

  • 1 Institute of Traditional Chinese Medicine and Pharmacology, Nanjing University of Traditional Chinese Medicine, People's Republic of China. gma@gamma.is.tuc.edu
PMID: 9461658 DOI: 10.1021/np970065o
Abstract

Two new pimarane Diterpenoids, lonchophylloids A (1) and B (2), were isolated from the stems of Ephemerantha lonchophylla. The structures of 1 and 2 were established predominantly through the application of extensive 1H-and 13C-NMR, 1D- and 2D-homonuclear and heteronuclear correlation NMR experiments, and X-ray diffraction methods. Consistent with structure--activity predictions, both compounds were capable of sensitizing cells that expressed the multidrug resistance phenotype to the toxicity of the Anticancer drug doxorubicin.

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