2. Academic Validation
  3. Cremimycin, a novel 19-membered macrocyclic lactam antibiotic, from Streptomyces sp

Cremimycin, a novel 19-membered macrocyclic lactam antibiotic, from Streptomyces sp

  • J Antibiot (Tokyo). 1998 Feb;51(2):123-9. doi: 10.7164/antibiotics.51.123.
M Igarashi 1,  T Tsuchida,  N Kinoshita,  M Kamijima,  R Sawa,  T Sawa,  H Naganawa,  M Hamada,  T Takeuchi,  K Yamazaki,  M Ishizuka
Affiliations

Affiliation

  • 1 Institute of Microbial Chemistry, Tokyo, Japan.
PMID: 9544932 DOI: 10.7164/antibiotics.51.123
Abstract

A novel 19-membered macrocyclic lactam Antibiotic, cremimycin, was isolated from the culture broth of an actinomycete strain. The producing organism, designated MJ635-86F5, was identified as a member of Streptomyces. Cremimycin was isolated from the mycelial cake by extraction with CHCl3-MeOH and precipitation with hexane-MeOH. The structure of cremimycin was determined by spectroscopic study. Cremimycin showed broad antimicrobial activities against Gram-positive bacteria including MRSA.

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