2. Academic Validation
  3. Cymbimicin A and B, two novel cyclophilin-binding structures isolated from actinomycetes

Cymbimicin A and B, two novel cyclophilin-binding structures isolated from actinomycetes

  • J Antibiot (Tokyo). 1997 Nov;50(11):893-9. doi: 10.7164/antibiotics.50.893.
T Fehr 1,  V F Quesniaux,  J J Sanglier,  L Oberer,  L Gschwind,  M Ponelle,  W Schilling,  S Wehrli,  A Enz,  G Zenke,  W Schuler
Affiliations

Affiliation

  • 1 Novartis Pharma Inc., Preclinical Research, Basel, Switzerland.
PMID: 9592559 DOI: 10.7164/antibiotics.50.893
Abstract

Two novel metabolites, cymbimicins A and B, were isolated from the culture broth of a strain of Micromonospora sp. by screening for Cyclophilin binding metabolites from actinomycete strains. Cymbimicin A binds to Cyclophilin A with a high affinity six fold lower than to that of cyclosporin A. The binding affinity of cymbimicin B is about 100 times lower. The taxonomy of the producing strain, fermentation, isolation, physical and biological properties and structure elucidation are described.

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