2. Academic Validation
  3. Purpurediolin and purpurenin, two new cytotoxic adjacent bis-tetrahydrofuran annonaceous acetogenins from the seeds of Annona purpurea

Purpurediolin and purpurenin, two new cytotoxic adjacent bis-tetrahydrofuran annonaceous acetogenins from the seeds of Annona purpurea

  • J Nat Prod. 1998 May;61(5):580-4. doi: 10.1021/np970410+.
D Chávez 1,  R Mata
Affiliations

Affiliation

  • 1 Departamento de Farmacia, Facultad de Química and Unidad de Investigación en Plantas Medicinales, Instituto de Química, Universidad Nacional Autónoma de México, D.F. 04510, Mexico.
PMID: 9599253 DOI: 10.1021/np970410+
Abstract

Two novel cytotoxic acetogenins, purpurediolin (1) and purpurenin (2), were isolated from the seeds of Annona purpurea. Their structures were elucidated by a combination of chemical and spectral methods including MS and NMR measurements. In addition, six known acetogenins were obtained, namely, bullatacin, squamocin (annonin I), motrilin (squamocin C), annoglaucin, xylomatenin, and annonacin A. Compounds 1 and 2 exhibited potent cytotoxic activity in vitro against six human solid tumor cell lines.

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