Glacins A and B: two novel bioactive mono-tetrahydrofuran acetogenins from Annona glabra

J Nat Prod. 1998 May;61(5):620-4. doi: 10.1021/np970563x.

X X Liu ¹, F Q Alali, E Pilarinou, J L McLaughlin

Affiliations

Affiliation

1 Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907, USA.

PMID: 9599260 DOI: 10.1021/np970563x

Abstract

Two new bioactive mono-THF Annonaceous acetogenins, glacins A (1) and B (2), have been isolated, from the fractionated ethanolic extracts of the leaves of Annona glabra, directing the fractionation with the brine shrimp lethality test (BST). The structures of 1 and 2 were elucidated on the basis of spectroscopic and chemical methods, and the absolute stereochemistries were solved by preparing their respective per-Mosher ester derivatives. 1 and 2 showed potent and selective in vitro cytotoxicities among several human solid tumor cell lines.

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