2. Academic Validation
  3. Antibacterial activity of lonchocarpol A

Antibacterial activity of lonchocarpol A

  • J Nat Prod. 1998 May;61(5):640-2. doi: 10.1021/np9703961.
M J Salvatore 1,  A B King,  A C Graham,  H R Onishi,  K F Bartizal,  G K Abruzzo,  C J Gill,  H G Ramjit,  S M Pitzenberger,  K M Witherup
Affiliations

Affiliation

  • 1 Merck Research Laboratories, Rahway, New Jersey 07065, USA. Michael_Salvatore@Merck.com
PMID: 9599265 DOI: 10.1021/np9703961
Abstract

Lonchocarpol A, a flavanone, demonstrates in vitro inhibitory activity against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium. This activity is antagonized by mouse plasma, which may account for its lack of in vivo activity. This compound demonstrates no differentiation with respect to the inhibition of RNA, DNA, cell wall, and protein synthesis.

Figures