2. Academic Validation
  3. Cytotoxic quassinoids from Simaba cedron

Cytotoxic quassinoids from Simaba cedron

  • J Nat Prod. 1998 Jun 26;61(6):776-80. doi: 10.1021/np980023f.
A Ozeki 1,  Y Hitotsuyanagi,  E Hashimoto,  H Itokawa,  K Takeya,  S de Mello Alves
Affiliations

Affiliation

  • 1 Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-03, Japan.
PMID: 9644063 DOI: 10.1021/np980023f
Abstract

Four new quassinoids, cedronolactones A-D (1-4), together with nine known compounds, simalikalactone D (5), chaparrinone (6), chaparrin (7), glaucarubolone (8), glaucarubol (9), samaderine Z (10), guanepolide (11), ailanquassin A (12), and polyandrol (13), were isolated from the wood of Simaba cedron. The chemical structures of 1-4 were elucidated on the basis of their chemical and spectral properties. Cedronolactone A (1) was shown to exhibit a significant in vitro cytotoxicity (IC50 0.0074 microg/mL) against P-388 cells.

Figures