Chemical constituents of Brazilian propolis and their cytotoxic activities

J Nat Prod. 1998 Jul;61(7):896-900. doi: 10.1021/np980028c.

A H Banskota ¹, Y Tezuka, J K Prasain, K Matsushige, I Saiki, S Kadota

Affiliations

Affiliation

1 Department of Natural Products Chemistry, Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University, 2630-Sugitani, Toya.

PMID: 9677271 DOI: 10.1021/np980028c

Abstract

The EtOAc-soluble fraction of the MeOH extract of propolis afforded a new prenylated chromane derivative, 3-hydroxy-2, 2-dimethyl-8-prenylchromane-6-propenoic acid (1), along with 22 known compounds, 2-23. Of the known compounds, 4, 7, 12-19, and 22 were isolated for the first time from propolis, and the absolute configuration of 23 was established as (2S,3R). Investigation suggested that Baccharis spp. are a significant source of tropical Brazilian propolis, in addition to Clusia minor, Clusia major, and Araucaria heterophylla. All the compounds were tested for their cytotoxicity toward human HT-1080 fibrosarcoma and murine colon 26-L5 carcinoma cells. Among these compounds, 9 and 19-21 showed potent cytotoxicity, having ED50 values equal to or less than 10 microg/mL.

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