2. Academic Validation
  3. Synthesis and cytotoxic activity of pyranocoumarins of the seselin and xanthyletin series

Synthesis and cytotoxic activity of pyranocoumarins of the seselin and xanthyletin series

  • J Nat Prod. 1998 Aug;61(8):982-6. doi: 10.1021/np9800295.
P Magiatis 1,  E Melliou,  A L Skaltsounis,  S Mitaku,  S Léonce,  P Renard,  A Pierré,  G Atassi
Affiliations

Affiliation

  • 1 Laboratory of Pharmacognosy, University of Athens, Panepistimiopolis, Zografou, GR-15771 Athens, Greece, and Institut de Recherche SERVIER, 11 rue des Moulineaux, 92150 Suresnes, France.
PMID: 9722480 DOI: 10.1021/np9800295
Abstract

The synthesis of known (3-6) and new (7-10 and 14-22) Coumarins in the seselin and xanthyletin series is described. The cytotoxic activity of compounds 3-22 was carried out in vitro on L-1210 cells. The most active compounds were 9, 16, 18, and 20 in the seselin series and 10, 17, and 19 in the xanthyletin series. Structure-activity relationships are discussed.

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