2. Academic Validation
  3. Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry

Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry

  • Science. 1998 Oct 23;282(5389):737-40. doi: 10.1126/science.282.5389.737.
S P Rohrer 1,  E T Birzin,  R T Mosley,  S C Berk,  S M Hutchins,  D M Shen,  Y Xiong,  E C Hayes,  R M Parmar,  F Foor,  S W Mitra,  S J Degrado,  M Shu,  J M Klopp,  S J Cai,  A Blake,  W W Chan,  A Pasternak,  L Yang,  A A Patchett,  R G Smith,  K T Chapman,  J M Schaeffer
Affiliations

Affiliation

  • 1 Department of Cell Biochemistry and Physiology, Merck Research Laboratories, Post Office Box 2000, Rahway, NJ 07065, USA. susanvrohrer@merck.com
PMID: 9784130 DOI: 10.1126/science.282.5389.737
Abstract

Nonpeptide agonists of each of the five somatostatin receptors were identified in combinatorial libraries constructed on the basis of molecular modeling of known peptide agonists. In vitro experiments using these selective compounds demonstrated the role of the somatostatin subtype-2 receptor in inhibition of glucagon release from mouse pancreatic alpha cells and the somatostatin subtype-5 receptor as a mediator of Insulin secretion from pancreatic beta cells. Both receptors regulated growth hormone release from the rat anterior pituitary gland. The availability of high-affinity, subtype-selective agonists for each of the somatostatin receptors provides a direct approach to defining their physiological functions.

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