2. Academic Validation
  3. High affinity, selective neurokinin 2 and neurokinin 3 receptor antagonists from a common structural template

High affinity, selective neurokinin 2 and neurokinin 3 receptor antagonists from a common structural template

  • Bioorg Med Chem Lett. 1998 Jun 2;8(11):1343-8. doi: 10.1016/s0960-894x(98)00215-7.
T Harrison 1,  M P Korsgaard,  C J Swain,  M A Cascieri,  S Sadowski,  G R Seabrook
Affiliations

Affiliation

  • 1 Department of Medicinal Chemistry, Merck Sharp Laboratory, Essex, U.K. timothy_harrison@merck.com
PMID: 9871763 DOI: 10.1016/s0960-894x(98)00215-7
Abstract

High affinity, selective hNK2 or hNK3 ligands can be prepared from the common template 1 in a few simple chemical operations. The hNK3 ligands 3 antagonise the calcium mobilisation caused by activation of hNK3 receptors expressed in CHO cells as measured using fura-2 microspectrofluorimetry.

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