2. Academic Validation
  3. Synthesis and antitumor activity of 4-phenyl-1-arylsulfonyl imidazolidinones

Synthesis and antitumor activity of 4-phenyl-1-arylsulfonyl imidazolidinones

  • Bioorg Med Chem Lett. 1998 Jun 16;8(12):1547-50. doi: 10.1016/s0960-894x(98)00261-3.
S H Jung 1,  H S Lee,  J S Song,  H M Kim,  S B Han,  C W Lee,  M Lee,  D R Choi,  J A Lee,  Y H Chung,  S J Yoon,  E Y Moon,  H S Hwang,  S K Seong,  D K Lee
Affiliations

Affiliation

  • 1 College of Pharmacy, Chungnam National University, Taejon, Korea.
PMID: 9873387 DOI: 10.1016/s0960-894x(98)00261-3
Abstract

Novel 1-(1-benzoylindoline-5-sulfonyl)-4-phenyl-4,5-dihydroimidazolon es 3 synthesized show highly potent and broad cytotoxicities. Among them compound 3b (DW2143) exhibits much more potent cytotoxicities than doxorubicin and highly effective antitumor activities against murine (3LL, Colon 26) and human xenograft (NCI-H23, SW620) tumor models.

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