2. Academic Validation
  3. SAR of novel biarylmethylamine dopamine D4 receptor ligands

SAR of novel biarylmethylamine dopamine D4 receptor ligands

  • Bioorg Med Chem Lett. 1998 Aug 4;8(15):2033-8. doi: 10.1016/s0960-894x(98)00361-8.
M Arlt 1,  H Böttcher,  A Riethmüller,  G Schneider,  G D Bartoszyk,  H Greiner,  C A Seyfried
Affiliations

Affiliation

  • 1 Med Chem ZNS, Darmstadt, Germany. m_arlt@merck.de
PMID: 9873481 DOI: 10.1016/s0960-894x(98)00361-8
Abstract

SAR for a novel series of dopamine D4 receptor ligands is shown. Very selective, highly potent compounds like 1-(2-pyrimidinyl)-4-(3-(3-thienyl)-benzyl)-piperazine (5f) and 2-(4-(1-fluorenylmethyl)-1-piperazinyl)-pyrimidine (8c) were obtained.

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