2. Academic Validation
  3. Thalidomide analogs and PDE4 inhibition

Thalidomide analogs and PDE4 inhibition

  • Bioorg Med Chem Lett. 1998 Oct 6;8(19):2669-74. doi: 10.1016/s0960-894x(98)00475-2.
G W Muller 1,  M G Shire,  L M Wong,  L G Corral,  R T Patterson,  Y Chen,  D I Stirling
Affiliations

Affiliation

  • 1 Celgene Corporation, Warren, NJ 07059 USA.
PMID: 9873600 DOI: 10.1016/s0960-894x(98)00475-2
Abstract

N-Phthaloyl 3-amino-3-arylpropionic acid analogs of thalidomide that are potent inhibitors of tumor necrosis factor-alpha are reported. These compounds were found to be potent inhibitors of phosphodiesterase 4.

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