2. Academic Validation
  3. Anti-inflammatory mechanism of alminoprofen: action on the phospholipid metabolism pathway

Anti-inflammatory mechanism of alminoprofen: action on the phospholipid metabolism pathway

  • Biochem Pharmacol. 1999 Feb 15;57(4):433-43. doi: 10.1016/s0006-2952(98)00312-8.
C Raguenes-Nicol 1,  F Russo-Marie,  G Domage,  N Diab,  E Solito,  F Dray,  J L Mace,  G Streichenberger
Affiliations

Affiliation

  • 1 INSERM U332, I.C.G.M., Paris, France.
PMID: 9933032 DOI: 10.1016/s0006-2952(98)00312-8
Abstract

Alminoprofen is a nonsteroidal anti-inflammatory drug (NSAID) of the phenylpropionic acid class. It has anti-inflammatory properties different from the classical NSAID. Using both in vitro systems of cells in culture and in vivo models of inflammation, we report here that alminoprofen possesses both antiphospholipase A2 (PLA2) activity and anti-cycloxygenase (COX) activity. The PLA2 targeted by alminoprofen is likely the secretory Phospholipase A2 (sPLA2) while the COX targeted is the COX-2.

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