2. Academic Validation
  3. Alternative products in the reaction of 2-nitro-5-thiocyanatobenzoic acid with thiol groups

Alternative products in the reaction of 2-nitro-5-thiocyanatobenzoic acid with thiol groups

  • Biochem J. 1976 Oct 1;159(1):177-80. doi: 10.1042/bj1590177.
N C Price
PMID: 999637 DOI: 10.1042/bj1590177
Abstract

2-Nitro-5-thiocyanatobenzoic acid has been proposed as a reagent for converting thiol groups in proteins into their S-cyano derivatives. Evidence was obtained for formation of both the S-cyano derivative and the mixed disulphide derivative. Formation of the S-cyano derivative can be promoted by addition of excess of CN-to the reaction mixture.

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