Mcl1-IN-12

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Mcl1-IN-12 (Compound F) is a selective Mcl-1 inhibitor, less potent at Bcl-2, with K_is of 0.29 and 3.1 μM, respectively. Anti-tumor activity.

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Mcl1-IN-12 Chemical Structure

CAS No. : 2042211-12-9

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Biological Activity
Purity & Documentation
References
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Description

Mcl1-IN-12 (Compound F) is a selective Mcl-1 inhibitor, less potent at Bcl-2, with K_is of 0.29 and 3.1 μM, respectively. Anti-tumor activity^[1].

IC₅₀ & Target

Ki: 0.29 (Mcl-1), 3.1 μM (Bcl-2)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
HL-60	IC₅₀	2.92 μM Compound: F	Growth inhibition of human HL60 cells after 72 hrs by MTT assay Growth inhibition of human HL60 cells after 72 hrs by MTT assay	[PMID: 27712939]
MCF7	IC₅₀	0.26 μM Compound: F	Growth inhibition of human MCF7 cells after 72 hrs by MTT assay Growth inhibition of human MCF7 cells after 72 hrs by MTT assay	[PMID: 27712939]
NCI-H23	IC₅₀	8.38 μM Compound: F	Growth inhibition of human NCI-H23 cells after 72 hrs by MTT assay Growth inhibition of human NCI-H23 cells after 72 hrs by MTT assay	[PMID: 27712939]
SK-OV-3	IC₅₀	7.83 μM Compound: F	Growth inhibition of human SKOV3 cells after 72 hrs by MTT assay Growth inhibition of human SKOV3 cells after 72 hrs by MTT assay	[PMID: 27712939]
U-266	IC₅₀	6.95 μM Compound: F	Growth inhibition of human U266 cells after 72 hrs by MTT assay Growth inhibition of human U266 cells after 72 hrs by MTT assay	[PMID: 27712939]

Molecular Weight

803.00

Formula

C₄₅H₄₆N₄O₆S₂

CAS No.

2042211-12-9

SMILES

O=C(NS(=O)(C1=CC=C(NCCSC2=CC=CC=C2)C([N+]([O-])=O)=C1)=O)C3=CC=C(NC(C(C=C4)=CC=C4C(C5=C(C)C=C(C(C)(C)CCC6(C)C)C6=C5)=C)=O)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wang M, et al. Design, synthesis, and activity evaluation of selective inhibitors of anti-apoptotic Bcl-2 proteins: The effects on the selectivity of the P1 pockets in the active sites. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5207-5211. [Content Brief]

Mcl1-IN-12 Related Classifications

Molarity Calculator
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mcl1-IN-122042211-12-9Bcl-2 FamilyInhibitorinhibitorinhibit

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