MCT1-IN-3 

MCT1-IN-3 is a monocarboxylate transporter 1 (MCT1) inhibitor with an IC₅₀ value of 81.0 nM. MCT1-IN-3 has also significant inhibitivity against the multidrug transporter ABCB1. MCT1-IN-3 can be used for the research of cancer^[1].

IC50: 81.0 nM (MCT1)^[1]
GI50: 20 μM (A-549); 15.1 μM (MCF-7)^[1]

MCT1-IN-3 (compound 24) has inhibitory activity for MCT1 with an IC₅₀ value of 81.0 nM^[1].
MCT1-IN-3 has great antiproliferative activities against the MCT1-expressing cancer cell lines A-549 and MCF-7 with GI₅₀ values of 20 μM and 15.1 μM, respectively^[1].
MCT1-IN-3 (5 μM; 24 h) leads to cancer cell cycle arrest as well as apoptosis^[1].
MCT1-IN-3 (1.0, 2.0, 3.5, and 5.0 μM) shows to sensitize these cancer cells toward an antineoplastic agent^[1].
MCT1-IN-3 has also significant inhibitory power against the multidrug transporter ABCB1 and shows to reverse ABCB1-mediated multidrug resistance (MDR) ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

389.40

C₂₂H₁₉N₃O₄

2878360-80-4

COC(/C(C#N)=C/C1=CN(C2=CC=CC=C12)CC(NC3=CC=C(C=C3)OC)=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Sachin Puri, et al. Indole Derivatives as New Structural Class of Potent and Antiproliferative Inhibitors of Monocarboxylate Transporter 1 (MCT1; SLC16A1). J Med Chem. 2023 Jan 12;66(1):657-676.  [Content Brief]