2. Apoptosis
  3. MDM-2/p53
  4. MDM2/4-p53-IN-1

MDM2/4-p53-IN-1 is a potent MDM2-p53 and MDM4-p53 inhibitor with IC50 values of 35.9, 57.4 nM, respectively. MDM2/4-p53-IN-1 shows antiproliferative activity.

For research use only. We do not sell to patients.

MDM2/4-p53-IN-1 Chemical Structure

MDM2/4-p53-IN-1 Chemical Structure

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MDM2/4-p53-IN-1 Related Antibodies

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Description

MDM2/4-p53-IN-1 is a potent MDM2-p53 and MDM4-p53 inhibitor with IC50 values of 35.9, 57.4 nM, respectively. MDM2/4-p53-IN-1 shows antiproliferative activity[1].

IC50 & Target

IC50: 35.9 nM (MDM2-p53); 57.4 nM (MDM4-p53)[1]
In Vitro

MDM2/4-p53-IN-1 (compound 3f) (0-100 µM; 48-96 h) shows antiproliferative activity with IC50 values of 20.9, 14.7, 11.5, 12.4 µM for HCT116, SJSA-1, LNCaP, MCF-7 cells, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MDM2/4-p53-IN-1 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: HCT116, SJSA-1, LNCaP, MCF-7 cells
Concentration: 0-100 µM
Incubation Time: 48 h (HCT116), 72 h (MCF7), 96 h (SJSA-1, LNCaP)
Result: Showed antiproliferative activity with IC50 values of 20.9, 14.7, 11.5, 12.4 µM for HCT116, SJSA-1, LNCaP, MCF-7 cells, respectively.
Molecular Weight

609.47

Formula

C32H22Cl2N6O3
SMILES

O=C1NC2=CC(Cl)=CC=C2[C@@]13N(C4=CC=C(Cl)C=C4)N=C([C@@H]3C5=CC(O)=CC=C5)C(NC6=CC(N7N=CC=C7)=CC=C6)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MDM2/4-p53-IN-1 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MDM2/4-p53-IN-1MDM-2/p53U87MGSHSY-5Y cellsantiproliferativeanticancerInhibitorinhibitorinhibit

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