2. Apoptosis
  3. MDM-2/p53 Apoptosis
  4. MDM2/4-p53-IN-2

MDM2/4-p53-IN-2 (2q) is a potent dual MDM2/ MDM4 inhibitor and p53 activator with the IC50 values of 70.7 nM for MDM2- p53 and 81.4 nM for MDM4-p53 complexes. MDM2/4-p53-IN-2 regulates the cell cycle, induces cell apoptosis and has anticancer activity.

For research use only. We do not sell to patients.

MDM2/4-p53-IN-2 Chemical Structure

MDM2/4-p53-IN-2 Chemical Structure

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MDM2/4-p53-IN-2 Related Antibodies

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Description

MDM2/4-p53-IN-2 (2q) is a potent dual MDM2/ MDM4 inhibitor and p53 activator with the IC50 values of 70.7 nM for MDM2- p53 and 81.4 nM for MDM4-p53 complexes. MDM2/4-p53-IN-2 regulates the cell cycle, induces cell apoptosis and has anticancer activity[1].

In Vitro

MDM2/4-p53-IN-2 (2q) (1-100 μM, 96 h) can inhibit the proliferation of cancer cells and induce cell apoptosis by targeting the G0/G1 cell cycle in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MDM2/4-p53-IN-2 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: Human cancer cell lines HCT116, SJSA-1, MCF-7, LNCaP, human embryonic kidney epithelial cell line HEK 293T
Concentration: 1-100 μM
Incubation Time: 48 hours
Result: Showed anti-proliferative activity of HCT116 with an IC50 value of 18.0 μM.
Showed well inhibition of cell viability against SJSA-1, MCF-7, LNCaP cells, all below 40%.
Reduced cell viability of HEK 293T cells by 24%.

Apoptosis Analysis[1]

Cell Line: SJSA-1 cell lines
Concentration: 15 and 22.5 μM
Incubation Time: 96 hours
Result: Increased LDH release by 1.3-fold and 1.6-fold at concentrations of 15 μM and 22.5 μM, respectively.
Caused a decrease in SJSA-1 cells, a significant decrease in cell growth and an increase in the number of early and late stage apoptotic cells at 22.5 μM.
Induced a significant accumulation of G0/G1 phase cells with a percentage of 67.5% at 15 μM and 82.2% at 22.5 μM, while reducing the percentage of S and G2/M phase cells.
Molecular Weight

532.78

Formula

C25H17Cl3FN3O3
SMILES

O=C(C([C@@H]1C2=CC=CC(Cl)=C2F)=NN(C3=CC=C(Cl)C=C3)[C@@]41C(NC5=C4C=CC(Cl)=C5)=O)OCC.[Relative stereochemistry]
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MDM2/4-p53-IN-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MDM2/4-p53-IN-2MDM-2/p53ApoptosisMDM2MDM4p53anticancerapoptosiscell cycleInhibitorinhibitorinhibit

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