MDM2/4-p53-IN-3

Cat. No.: HY-151171: FAQs
Data Sheet Handling Instructions

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MDM2/4-p53-IN-3 is a MDM2/4-p53 protein-protein interactions (PPIs) inhibitor (IC₅₀s: 18.5 nM for MDM2-p53, 14.8 nM for MDM4-p53). MDM2/4-p53-IN-3 can be used in the research of cancers, such as colon cancer.

For research use only. We do not sell to patients.

MDM2/4-p53-IN-3 Chemical Structure

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Description

IC₅₀ & Target

MDM2/4-p53 protein-protein interactions (PPIs)^[1]

In Vitro

MDM2/4-p53-IN-3 (Compound 2a, 1-100 μM, 48 h) inhibits cell proliferation^[1].
MDM2/4-p53-IN-3 dissociates p53-MDMs complexes (immunoenzymatic assays) with IC₅₀ values of 18.5 nM (MDM2-p53) and 14.8 nM (MDM4-p53)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	HCT116, SJSA-1, LNCaP, MCF-7
Concentration:	1-100 μM
Incubation Time:	48 h (HCT116), 72 h (MCF-7), 96 h (SJSA-1, LNCaP)
Result:	Inhibited cell proliferation with IC₅₀ values of 23.6 μM (HCT116), 12.6 μM (SJSA-1), 13.1 μM (LNCaP), 14.3 μM (MCF-7).

Molecular Weight

504.38

Formula

C₂₅H₂₄Cl₂FN₃O₃

SMILES

O=C(C([C@@H]1C2=CC=CC(Cl)=C2F)=NN(C3CCCCC3)[C@@]41C(NC5=C4C=CC(Cl)=C5)=O)OCC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Margarida Espadinha, et al. Discovery of MDM2-p53 and MDM4-p53 protein-protein interactions small molecule dual inhibitors. Eur J Med Chem. 2022 Aug 5;241:114637. [Content Brief]

MDM2/4-p53-IN-3 Related Classifications

Molarity Calculator
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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MDM2/4-p53-IN-3MDM-2/p53CancerHCT116p53-MDM PPIcolon cancercarcinogenesisInhibitorinhibitorinhibit

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