2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. MDTF

MDTF is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

MDTF Chemical Structure

MDTF Chemical Structure

Size Price Stock Quantity
5 mg USD 500 In-stock
10 mg USD 850 In-stock
25 mg USD 1750 In-stock
50 mg USD 2800 In-stock
100 mg USD 4500 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of MDTF:

MDTF Related Antibodies

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  • Biological Activity

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  • Customer Review

Description

MDTF is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

In Vitro

MDTF (50 μM) increases hydrophilic character by substitution of a cyclohexyl ring and a MD-based FRET probe incubates in human plasma has a considerably higher self-stabilization rate compared to the MCC-based probe[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MDTF Related Antibodies
Molecular Weight

491.30

Formula

C16H10F4NNaO9S
Appearance

Solid

Color

White to off-white

SMILES

O=C([C@H]1CO[C@H](OC1)CN2C(C=CC2=O)=O)OC3=C(C(F)=C(C(F)=C3F)S(=O)(O[Na])=O)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (203.54 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0354 mL 10.1771 mL 20.3542 mL
5 mM 0.4071 mL 2.0354 mL 4.0708 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0354 mL 10.1771 mL 20.3542 mL 50.8854 mL
5 mM 0.4071 mL 2.0354 mL 4.0708 mL 10.1771 mL
10 mM 0.2035 mL 1.0177 mL 2.0354 mL 5.0885 mL
15 mM 0.1357 mL 0.6785 mL 1.3569 mL 3.3924 mL
20 mM 0.1018 mL 0.5089 mL 1.0177 mL 2.5443 mL
25 mM 0.0814 mL 0.4071 mL 0.8142 mL 2.0354 mL
30 mM 0.0678 mL 0.3392 mL 0.6785 mL 1.6962 mL
40 mM 0.0509 mL 0.2544 mL 0.5089 mL 1.2721 mL
50 mM 0.0407 mL 0.2035 mL 0.4071 mL 1.0177 mL
60 mM 0.0339 mL 0.1696 mL 0.3392 mL 0.8481 mL
80 mM 0.0254 mL 0.1272 mL 0.2544 mL 0.6361 mL
100 mM 0.0204 mL 0.1018 mL 0.2035 mL 0.5089 mL
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MDTF Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MDTFADC LinkerAntibody-drug conjugates linkerSMCCADC linkerhydrophiliccyclohexyl ringself-stabilizationInhibitorinhibitorinhibit

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