2. PROTAC
  3. PROTAC Linkers
  4. Me-PEG4-Me

Me-PEG4-Me  (Synonyms: Tetraglyme)

Cat. No.: HY-W013522 Purity: 98.57%
COA Handling Instructions

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Me-PEG4-Me is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Me-PEG4-Me Chemical Structure

Me-PEG4-Me Chemical Structure

CAS No. : 143-24-8

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500 g USD 28 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Me-PEG4-Me:

Me-PEG4-Me Related Antibodies

Top Publications Citing Use of Products

View All PROTAC Linkers Isoform Specific Products:

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Me-PEG4-Me is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Me-PEG4-Me Related Antibodies
Molecular Weight

222.28

Formula

C10H22O5
CAS No.
Appearance

Liquid (Density: 1.009  g/cm3  )

Color

Colorless to light yellow

SMILES

COCCOCCOCCOCCOC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (449.88 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4988 mL 22.4942 mL 44.9883 mL
5 mM 0.8998 mL 4.4988 mL 8.9977 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.93%

COA (239 KB) HNMR (115 KB) GC (188 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.4988 mL 22.4942 mL 44.9883 mL 112.4708 mL
5 mM 0.8998 mL 4.4988 mL 8.9977 mL 22.4942 mL
10 mM 0.4499 mL 2.2494 mL 4.4988 mL 11.2471 mL
15 mM 0.2999 mL 1.4996 mL 2.9992 mL 7.4981 mL
20 mM 0.2249 mL 1.1247 mL 2.2494 mL 5.6235 mL
25 mM 0.1800 mL 0.8998 mL 1.7995 mL 4.4988 mL
30 mM 0.1500 mL 0.7498 mL 1.4996 mL 3.7490 mL
40 mM 0.1125 mL 0.5624 mL 1.1247 mL 2.8118 mL
50 mM 0.0900 mL 0.4499 mL 0.8998 mL 2.2494 mL
60 mM 0.0750 mL 0.3749 mL 0.7498 mL 1.8745 mL
80 mM 0.0562 mL 0.2812 mL 0.5624 mL 1.4059 mL
100 mM 0.0450 mL 0.2249 mL 0.4499 mL 1.1247 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Me-PEG4-Me Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Me-PEG4-Me143-24-8TetraglymePROTAC LinkersInhibitorinhibitorinhibit

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