2. PROTAC
  3. PROTAC Linkers
  4. Me-Tet-PEG4-NH2 hydrochloride

Me-Tet-PEG4-NH2 (hydrochloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Me-Tet-PEG4-NH2 (hydrochloride) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

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Me-Tet-PEG4-NH2 hydrochloride Chemical Structure

Me-Tet-PEG4-NH2 hydrochloride Chemical Structure

CAS No. : 2656478-51-0

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5 mg USD 110 In-stock
10 mg USD 176 In-stock
25 mg USD 350 In-stock
50 mg USD 560 In-stock
100 mg USD 900 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Me-Tet-PEG4-NH2 hydrochloride:

Me-Tet-PEG4-NH2 hydrochloride Related Antibodies

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Description

Me-Tet-PEG4-NH2 (hydrochloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Me-Tet-PEG4-NH2 (hydrochloride) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Me-Tet-PEG4-NH2 hydrochloride Related Antibodies
Molecular Weight

484.98

Formula

C21H33ClN6O5
CAS No.
Appearance

Oil

Color

Purple to purplish red

SMILES

CC1=NN=C(N=N1)C2=CC=C(C=C2)CNC(CCOCCOCCOCCOCCN)=O.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

Methanol : 125 mg/mL (257.74 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0619 mL 10.3097 mL 20.6194 mL
5 mM 0.4124 mL 2.0619 mL 4.1239 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Methanol 1 mM 2.0619 mL 10.3097 mL 20.6194 mL 51.5485 mL
5 mM 0.4124 mL 2.0619 mL 4.1239 mL 10.3097 mL
10 mM 0.2062 mL 1.0310 mL 2.0619 mL 5.1549 mL
15 mM 0.1375 mL 0.6873 mL 1.3746 mL 3.4366 mL
20 mM 0.1031 mL 0.5155 mL 1.0310 mL 2.5774 mL
25 mM 0.0825 mL 0.4124 mL 0.8248 mL 2.0619 mL
30 mM 0.0687 mL 0.3437 mL 0.6873 mL 1.7183 mL
40 mM 0.0515 mL 0.2577 mL 0.5155 mL 1.2887 mL
50 mM 0.0412 mL 0.2062 mL 0.4124 mL 1.0310 mL
60 mM 0.0344 mL 0.1718 mL 0.3437 mL 0.8591 mL
80 mM 0.0258 mL 0.1289 mL 0.2577 mL 0.6444 mL
100 mM 0.0206 mL 0.1031 mL 0.2062 mL 0.5155 mL
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Me-Tet-PEG4-NH2 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Me-Tet-PEG4-NH22656478-51-0PROTAC LinkersInhibitorinhibitorinhibit

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