Meclizine-d₈  (Synonyms: Meclozine-d₈)

Meclizine-d₈ is a deuterium labeled Meclizine. Meclizine is a histamine H1 receptor antagonist and has the potential to treat nausea and motion sickness. Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for Human CAR[1][2][3].

Histamine H1 Receptor.

399.00

C₂₅H₁₉D₈ClN₂

1246816-06-7

31884-77-2

ClC(C=C1)=CC=C1C(C2=CC=CC=C2)N3C([2H])([2H])C([2H])([2H])N(C([2H])([2H])C3([2H])[2H])CC4=CC=CC(C)=C4

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Priti N. Patel, et al. Safety and Efficacy in the Treatment and Prevention of Motion Sickness.

  [2]. Vishal M Gohil, et al. Meclizine is neuroprotective in models of Huntington's disease. Hum Mol Genet. 2011 Jan 15;20(2):294-300.  [Content Brief]

  [3]. Wendong Huang, et al. Meclizine Is an Agonist Ligand for Mouse Constitutive Androstane Receptor (CAR) and an Inverse Agonist for Human CAR.  [Content Brief]