2. Anti-infection Protein Tyrosine Kinase/RTK
  3. Bacterial c-Met/HGFR Antibiotic
  4. Meleagrin

Meleagrin is a roquefortine C-derived alkaloid produced by fungi of the genus Penicillium and has antimicrobial and anti-proliferative activities. Meleagrin is a class of FabI inhibitor. Meleagrin is a lead c-Met inhibitory entity useful for the control of c-Met-dependent metastatic and invasive breast malignancies.

For research use only. We do not sell to patients.

Meleagrin Chemical Structure

Meleagrin Chemical Structure

CAS No. : 71751-77-4

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Based on 1 publication(s) in Google Scholar

Meleagrin Related Antibodies

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Description

Meleagrin is a roquefortine C-derived alkaloid produced by fungi of the genus Penicillium and has antimicrobial and anti-proliferative activities. Meleagrin is a class of FabI inhibitor. Meleagrin is a lead c-Met inhibitory entity useful for the control of c-Met-dependent metastatic and invasive breast malignancies[1][2][3].

In Vitro

Meleagrin inhibits the growth of the human breast cancer cell lines MDA-MB-231, MDA-468, BT-474, SK BR-3, MCF7 and MCF7-dox[3].
Meleagrin causes a dose-dependent inhibition of HGF-induced cell migration, and invasion of breast cancer cell lines[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Meleagrin Related Antibodies
In Vivo

Meleagrin potently suppresses the invasive triple negative breast tumor cell growth in an orthotopic athymic nude mice model[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

433.46

Formula

C23H23N5O4
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1N[C@@]23N(OC)C4=C(C=CC=C4)[C@]2(C(C)(C)C=C)C=C(O)C(N3/C1=C/C5=CN=CN5)=O
Structure Classification
Initial Source

marine fungus Emericella dentata Nq45
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation

Purity: ≥99.0%

COA (263 KB)

Handling Instructions (2659 KB)
References
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Meleagrin Related Classifications

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Meleagrin71751-77-4Bacterialc-Met/HGFRAntibioticInhibitorinhibitorinhibit

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